Figure 4.

Kinetics of plasma IgA levels and IgA deposition in glomeruli of 1-week-old to 3-month-old α1KI and α1KI J−/− mice. (A) IgA was measured by ELISA in mice housed in CIS facilities (means±SEM of n=4–8 mice; Kruskall–Wallis test followed by Bonferroni test). *P<0.05; **P<0.01. (B) IgA deposits (green) by fluorescence microscopy on representative kidney sections from groups of four to eight mice housed in CIS facilities. (C) IgA kidney deposits compared on representative kidney sections from groups of 6-week-old α1KI J−/− mice housed under either SOPF or CIS conditions.