Table 2.

AKI models in Nlrp3-, Asc-, Casp1/11-, Il-1α­–, and Il-β–deficient mice

Disease Model	Gene	Inflammation	Renal Function	Reference
Severe GN
Heterologous anti-GBM GN	Nlrp3−/−	—	—	63
	Asc−/−	—	—	63
	Casp1/11−/−	—	—	63
Autologous anti-GBM GN	Nlrp3−/−	↓	Better	86
	Asc−/−	↓	Better	86
	IL1β−/−	↓	Better	84,85
Sepsis
LPS-induced	Casp1/11−/−	↓	Better	120
Tubular necrosis
Ischemia- reperfusion	Nlrp3−/−	—	Better	76,77,79
	Asc−/−	—	—	76
	Casp1/11−/−	↓	Better	121
	IL1α−/−	↓	?	122
	IL1β−/−	↓	?	122
Cisplatin	Nlrp3−/−	—	—	79
	Asc−/−	?	?	123
	Casp1/11−/−	↓	Better	118
	IL1α−/−-	—	Better	80
Rhabdomyolysis	Nlrp3−/−	↓	Better	75
	Asc−/−	↓	Better	75
	Casp1/11−/−	↓	Better	75
	IL1β−/−	↓	Better	75
Acute oxalosis	Nlrp3−/−	↓	Better	21
	Asc−/−	↓	Better	21
	Casp1/11−/−	↓	Better	21

Anti-GBM GN, anti-glomerular basement membrane GN; —, absent; ↓, suppressed; ?, unknown.