Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Model of hypoxia-induced miR-147a in regulating cell proliferation and its role in positive feedback. Hypoxia induced HIF-1α and HNF4A expression. HIF-1α increases the expression of miR-147a through interacting with HNF4A. MiR-147a promotes the stability of HIF-1α by targeting HIF-3α. The accumulation of HIF-1α increases the expression of downstream gene, which contribute to cell proliferation arrest.
