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Concept of a hybrid cell after fusion of a CTC with macrophages to induce immune tolerance. CTC culturing from melanoma and colorectal cancer patients with a density centrifugation technique revealed CK+ CTCs that express pan-macrophage marker CD14 and leucocyte marker CD45. It can be hypothesized that CTCs capable to spread and replicate in other organs induce immune tolerance by fusing with macrophages and expressing tumor antigens to the host immune system.
