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A partial picture of) the SREBP regulatory network. The LATS2-WTp53 axis (A) inhibits processing of P-SREBP (B) and transcription of SREBP mRNA (C). Mutant p53 (mutp53) binds N-SREBP and augments its transcriptional activity (D). YAP/2AZ are dependent on the mevalonate pathway for their activity (E). AMPK inhibits processing of P-SREBP (F). RNF20 ubiquitinates SREBP and drives its degradation (G).
