Figure 4.

Anti-HMGB1 mAb treatment of MRL/lpr mice does not affect renal pathology and renal immune complex deposition. (A) Representative pictures of PAS, H&E, C3 and IgG staining in kidney sections of 17-wk-old MRL/MPJ and MRL/lpr mice (10×). Inserts show a glomerulus in detail (40×). (B) Quantitative analysis of C3 and IgG deposition in kidney sections of 17-wk-old MRL/MPJ and MRL/lpr mice. Box and whiskers plot, median and interquartile range are shown for n = 8–11 mice per group. A Kruskal-Wallis test was used to test for overall differences between the three groups. To investigate which group was different, further testing was performed to compare groups separately using a Mann-Whitney U test. *p < 0.05