Figure 1.

Effect of the combined treatment on organ injury makers and systemic inflammation in aged septic rats. Rats were sham operated or subjected to CLP with injection of vehicle (normal saline) or human ghrelin plus GH at two different doses, GG-1 (40 nmol/kg of ghrelin and 25 μg/kg GH) and GG-2 (80 nmol/kg of ghrelin and 50 μg/kg of GH) at 5 h after CLP. Blood samples were collected at 20 h after CLP for measuring (A) lactate, (B) LDH, (C) BUN, (D) creatinine, (E) IL-6 and (F) TNF-α. Data are expressed as mean ± SE (n = 5–7 per group). *P < 0.05 versus sham and ^#P < 0.05 versus vehicle.