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. 2016 May 24;22:202–214. doi: 10.2119/molmed.2016.00033

Figure 4.

Figure 4.

NE–/–/CG–/– and NE–/–/PR3–/–mice have reduced inflammation after a high-fat diet. (A) Representative images of immunostaining of the macrophage marker F4/80 in white adipose tissue of wild-type, NE–/–/CG–/–and NE–/–/PR3–/– mice. (B) Average number of macrophages per field. (C) Average number of CLS per field. Secretion of (D) IL-6 and (E) KC by white adipose tissue explants. (F) Relative mRNA expression of IL-1b, Cd68, IL-6, Mcp-1 and IL-1Ra in liver. WT, wild-type; HFD, high-fat diet; CLS, crown-like structures; *significant difference p ≤ 0.05; **significant difference p ≤ 0.01 ***significant difference p ≤ 0.001; NS, nonsignificant.