Figure 6.

Treatment with α-1 antitrypsin improves NAFLD status and reduces fasting glucose during the last 10 d of a high-fat diet. (A) Bodyweight of mice after a low-fat diet and treated with vehicle and after a high-fat diet treated with either vehicle or α-1 antitrypsin. (B) Fasting glucose levels. (C) HE staining of liver sections. (D) Percentage of lipid droplets in HE-stained liver sections, liver weights and liver triglycerides. LFD, low-fat diet; HFD, high-fat diet; hAAT, human α-1 antitrypsin; TG, triglycerides; **significant difference p ≤ 0.01; ***significant difference p ≤ 0.001; NS, nonsignificant.