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Cyclopamine inhibits proximal cartilage induction. (A-C) Lizard tail blastema explants (9 DPA) were treated with vehicle control (A), cyclopamine (B) or cyclopamine and SAG (C) and analyzed by Col2 immunostaining to assess the role of hedgehog signaling in proximal CC formation. (D-F) Higher magnification views of regions identified in A-C analyzed by Ihh immunostaining. Dashed lines trace vertebral boundaries. cc, cartilage callus; ct, cartilage tube; ve, vertebra. Scale bars: 50 µm.
