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. 2016 Aug 1;143(15):2716–2723. doi: 10.1242/dev.123935

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© 2016. Published by The Company of Biologists Ltd

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0), which permits unrestricted use, distribution and reproduction in any medium provided that the original work is properly attributed.

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Fig. 4. — Aebp2^tr/tr cells show a small increase in H3K27me3 at PRC2 target sites. (A) Immunoblot of global H3K27me0/1/2/3 levels in Aebp2 WT and Aebp2^tr/tr mESCs. (B) ChIP-seq profile for H3K27me3, SUZ12 and input in Aebp2 WT and Aebp2^tr/tr mESCs at the Sfrp1 gene. (C) A metaplot of H3K27me3 ChIP-seq signal at AEBP2 sites in Aebp2 WT and Aebp2^tr/tr mESCs plotted across a 10 kb window for two repeats of the ChIP-seq experiment.