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Failure to thrive and muscle hypoplasia phenotype in MRTF dKO mice. (A) HdKO mice at P1 and P3 show failure to thrive and reduced muscle mass. Control: MRTF-A+/−; MRTF-Bflox/flox. (B) H&E staining of coronal sections of tongue and transverse sections of hindlimb demonstrate reduced fiber size in dKO mice, compared with control (MRTF-A+/−; MRTF-Bflox/flox). Scale bar: 40 μm.
