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. 2016 Aug 15;126(9):3417–3432. doi: 10.1172/JCI85880

Figure 7. CAPN6 is induced in murine atheromas and exacerbates atherosclerotic diseases.

Figure 7

(A) Aortic expression of calpain family genes in chow- or HFD-fed Ldlr–/– mice. Mice received chow or HFD for 12 weeks. (B) Loss of Capn6 reduces aortic atherosclerosis in Ldlr–/– mice independently of sex. (C) Capn6 deficiency does not ameliorate plasma dyslipidemia in Ldlr–/– mice. (D) Capn6 promoter is activated specifically in atherosclerotic lesions. Capn6+/yLdlr−/− mice served as a negative control. (E) CAPN6 was localized in macrophages in murine atherosclerotic lesions. MOMA2 served as a macrophage marker. **P < 0.01; *P < 0.05, 1-way ANOVA followed by Bonferroni’s test (A, B and C); error bars represent mean ± SEM. Scale bars: 100 μm (D); 25 μm (E).