Table 1.
Conditions for the preparation of mPEG-g-chitosan with different grafting efficiencies. The nomenclature used herein defines mPEG-g13-chitosan as mPEG-g-chitosan with a grafting efficiency of 13% (molar ratio) as determined via 1H NMR. The number “n” following the “g” in mPEG-gn-chitosan denotes the percent of PEGylation.
| Sample | mPEG-acid (g) | Chitosan (g) | EDC (g) | NHS (g) |
|---|---|---|---|---|
| mPEG-g5-Chitosan | 0.43 | 0.50 | 0.20 | 0.12 |
| mPEG-g6-Chitosan | 0.43 | 0.45 | 0.20 | 0.12 |
| mPEG-g7-Chitosan | 0.43 | 0.40 | 0.20 | 0.12 |
| mPEG-g8-Chitosan | 0.43 | 0.35 | 0.20 | 0.12 |
| mPEG-g11-Chitosan | 0.43 | 0.30 | 0.20 | 0.12 |
| mPEG-g13-Chitosan | 0.43 | 0.25 | 0.20 | 0.12 |