Table 1.
Characteristics of patients with PTMC with LNM identified from the SEER database
| Variable | Total | CLNM-negative | CLNM-positive | P-value | LLNM-negative | LLNM-positive | P-value |
|---|---|---|---|---|---|---|---|
| Total | 31,017 (100.0) | 28,882 (93.1) | 2,135 (6.9) | 29,333 (94.6) | 1,684 (5.4) | ||
| Sex | |||||||
| Male | 5,725 (18.5) | 5,201 (18.0) | 524 (24.5) | 0.001 | 5,117 (17.4) | 608 (36.1) | 0.001 |
| Female | 25,292 (81.5) | 23,681 (82.0) | 1,611 (75.5) | 24,216 (82.6) | 1,076 (63.9) | ||
| Age (years) | |||||||
| <45 | 10,272 (33.1) | 9,362 (32.4) | 910 (42.6) | 0.001 | 9,485 (32.3) | 787 (46.7) | 0.001 |
| ≥45 | 20,745 (66.9) | 19,520 (67.6) | 1,225 (57.4) | 19,848 (67.7) | 897 (53.3) | ||
| Race | |||||||
| Black | 1,907 (6.1) | 1,837 (6.4) | 70 (3.3) | 0.001 | 1,872 (6.4) | 35 (2.1) | 0.001 |
| White | 25,958 (83.7) | 24,139 (83.6) | 1,819 (85.2) | 24,518 (83.6) | 1,440 (85.5) | ||
| Othera | 2,784 (9.0) | 2,573 (8.9) | 211 (9.9) | 2,597 (8.9) | 187 (11.1) | ||
| Size (mm) | 5.4±3.0 | 5.3±3.0 | 6.9±2.7 | 0.001 | 5.4±3.0 | 6.7±2.7 | 0.001 |
| Histology | |||||||
| FV-PTMC | 22,482 (72.5) | 20,771 (71.9) | 1,711 (80.1) | 0.001 | 21,113 (72.0) | 1,369 (81.3) | 0.001 |
| Papillary | 8,535 (27.5) | 8,111 (28.1) | 424 (19.9) | 8,220 (28.0) | 315 (18.7) | ||
| Multifocality | 10,751 (34.7) | 9,664 (35.5) | 1,087 (50.9) | 0.001 | 9,763 (33.3) | 988 (58.7) | 0.001 |
| ETE | |||||||
| Capsule | 1,000 (3.2) | 910 (3.2) | 90 (4.2) | 0.001 | 904 (3.1) | 96 (5.7) | 0.001 |
| Minimal | 1,643 (5.3) | 1,330 (4.6) | 313 (14.7) | 1,297 (4.4) | 346 (20.5) | ||
| Gross | 161 (0.5) | 135 (0.5) | 26 (1.2) | 112 (0.4) | 49 (2.9) | ||
| Metastasisb | 92 (0.3) | 81 (0.3) | 11 (0.5) | 0.001 | 46 (0.2) | 46 (2.7) | 0.001 |
| TT | 23,572 (76.0) | 21,661 (75.0) | 1,911 (89.5) | 21,979 (74.9) | 1,593 (94.6) | 0.001 | |
| Radioisotopes | 8,886 (28.6) | 7,585 (26.3) | 1,301 (60.9) | 0.001 | 7,688 (26.2) | 1,198 (71.1) | 0.001 |
Notes: Data are presented as n (%) or mean ± standard deviation.
a
Including American Indian/Alaska Native and Asian/Pacific Islander.
b
Including the lungs, bones, and brains.
Abbreviations: PTMC, papillary thyroid microcarcinoma; SEER, Surveillance, Epidemiology, and End Results; LNM, lymph node metastasis; CLNM, central lymph node metastasis; LLNM, lateral lymph node metastasis; FV-PTMC, follicular variant of papillary thyroid microcarcinoma; ETE, extrathyroidal extension; TT, total thyroidectomy.