Table 4.

Association of -216G/T, R497K, and CA-SSR1 genotype/allele frequencies in EGFR with the risk of pleural metastasis of lung adenocarcinoma

Genotype and allele	Nonpleural metastasis group (n=424)		Pleural metastasis group (n=432)		OR (95% CI)	Adjusted ORb (95% CI)	Adjusted P
	na	%	na	%
G/G	249	58.73	203	46.99	1.00	1.00 (ref)	1.00 (ref)
G/T	143	33.73	174	40.28	1.42 (1.015–1.826)	1.57 (1.124–1.912)	0.032
T/T	32	7.55	55	12.73	1.65 (1.026–3.015)	1.86 (1.043–3.225)	0.004
G	641	75.59	580	67.13	1.00 (ref)
T	207	24.41	284	32.87	1.61 (1.228–1.916)		0.021
Arg/Arg	107	25.24	175	40.51	1.00 (ref)	1.00 (ref)	1.00 (ref)
Arg/Lys	218	51.42	205	47.45	1.14 (1.008–1.314)	1.18 (1.014–1.363)	0.087
Lys/Lys	99	23.35	52	12.04	1.87 (1.074–3.086)	1.94 (1.081–3.162)	0.038
Arg	432	50.94	555	64.24	1.00 (ref)
Lys	416	49.06	309	35.76	1.76 (1.237–1.982)		0.016
CA-SSR1 polymorphism
Main genotype
16/16	37	8.73	94	21.76	1.00 (ref)	1.00 (ref)	1.00 (ref)
18/18	24	5.67	27	6.25	1.43 (1.032–1.764)	1.48 (1.415–1.845)	0.132
16/20	21	4.95	19	4.40	1.73 (1.067–2.034)	1.84 (1.301–2.849)	0.264
20/20	109	25.71	76	17.59	1.94 (1.074–2.077)	1.59 (1.075–3.002)	0.034
Main allele
16	83	9.79	153	17.71	1.00 (ref)
18	76	8.96	56	6.48	1.66 (1.037–1.768)		0.056
20	166	19.58	125	14.47	1.68 (1.024–3.218)		0.018

Notes:

^aThe number of patients for the genotype and the allele.

^bAdjusted for age, sex, smoking status, and differential grade of tumor cells. n^a was the number of patients for the genotype and the allele. Adjusted P-values were derived from the Cox proportional hazards regression model, adjusted OR^b and adjusted P-values were adjusted by age, sex, smoking status and differential grade of tumor cells.

Abbreviations: CA-SSR1, CA simple sequence repeat in intron 1; OR, odds ratio; 95% CI, 95% confidence interval.