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. 2016 Aug 30;11(8):e0159095. doi: 10.1371/journal.pone.0159095

Fig 7. Correlation plots of the panel of inflammatory biomarkers in serum and synovial fluid before and after autologous bone marrow-derived mesenchymal stem cell (BM-MSC) injection.

Fig 7

(A,B) In serum, strong positive correlations between CXCL1, CXCL8, and CCL2 and CRP became much weaker after BM-MSC injection. The weak correlation between IL-7 and CRP became much stronger after BM-MSC injection. (C,D) In synovial fluid from the complete CR stifle, correlation of CCL2 and TNFα with other cytokines was strengthened after BM-MSC injection. The strong correlation between CRP and IL-10 became much weaker after BM-MSC injection. (EF) In synovial fluid from the stable partial CR stifle, cytokines in the network were weakly correlated before treatment and these correlations because much stronger after BM-MSC injection, with the exception of CXCL1. Correlations between CRP and IL-6, IL-10, CXCL1 and CXCL8 became much weaker after BM-MSC injection.