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. 2016 Aug 30;11(8):e0159095. doi: 10.1371/journal.pone.0159095

Fig 8. Bayesian networks derived from a panel of inflammatory biomarkers in serum and synovial fluid before and after autologous bone marrow-derived mesenchymal stem cell (BM-MSC) injection.

Fig 8

(A) In serum, CRP was influenced by IL-7 and IL-10 as well BM-MSC injection. CXCL8 and IL-18 were also influenced by BM-MSC injection and in turn IL-18 influenced IFNγ concentrations. (B) In synovial fluid in the complete CR stifle, there was a complex network in which CRP, CXCL1, GM-CSF, and IL-10 showed conditional dependencies with BM-MSC injection. Ultimately, TNFα concentrations were strongly influenced by several pro-inflammatory cytokines. (C) In synovial fluid in the stable partial CR stifle, there was a much less complex network in which no strong dependencies on BM-MSC injection were identified. CRP, CCL2, CXCL8 and IL-10 were weakly influenced by BM-MSC injection. The orange node indicates the time-dependent effect of BM-MSC injection. The light blue colored nodes indicate the Markov blankets of the network that identify a subset of cytokines directly influenced by BM-MSC injection. Thicker arcs indicate higher connection strength between nodes (i.e. variables).