TABLE 3.
Reasons for Discontinuation of 104 RCTs
| Reason | n, (%) |
|---|---|
| Patient accrual | 38 (36.5) |
| Conduct problemsa | 13 (12.5) |
| Informative terminationb | 13 (12.5) |
| Company/business decision | 9 (8.7) |
| Principle investigator left | 8 (7.7) |
| Regulatory issuec | 8 (7.7) |
| Funding issue | 5 (4.8) |
| None reported or unclear | 10 (9.6) |
a
Includes technical difficulties and logistical issues.
b
Includes changes in standard of care and safety or efficacy findings.
c
Includes issues with institutional review board or other regulatory body, including the FDA.