TABLE 6.
Multivariate Analysis of Factors Associated with Nonpublication of RCTs at 24 and 36 months After Trial Completion
| Unpublished at 24 mo, OR (95% CI) | P | Unpublished at 36 mo, OR (95% CI)a | P | |
|---|---|---|---|---|
| Intervention | ||||
| Behavioral | Reference | Reference | ||
| Drug/biologic | 1.36 (0.61–2.99) | .45 | 1.09 (0.36–3.35) | .88 |
| Device/procedure | 0.81 (0.29–2.28) | .69 | 0.72 (0.15–3.33) | .67 |
| Dietary supplement | 1.50 (0.57–3.94) | .42 | 1.66 (0.45–6.10) | .44 |
| Other | 1.12 (0.41–3.02) | .83 | 1.13 (0.30–4.35) | .85 |
| Primary funding source | ||||
| Academia | Reference | Reference | ||
| Industry | 2.21 (1.35–3.64) | .002 | 3.12 (1.60–6.08) | <.001 |
| Other | 1.37 (0.64–2.93) | .42 | 1.95 (0.74–5.15) | .18 |
| Masking | ||||
| Open label | Reference | Reference | ||
| Single blind | 1.15 (0.62–2.16) | .65 | 0.97 (0.43–2.20) | .94 |
| Double blind | 1.19 (0.77–1.84) | .44 | 1.26 (0.75–2.14) | .38 |
| Enrolled participants/ actual sample size | 1.00 (1.00–1.00) | .82 | 1.00 (1.00–1.00) | .31 |
a
Six trials were excluded from this analysis because 36 mo had not elapsed between completion date and time that publication search was conducted.