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The crystal structures of 1HDC and the designed protein DIG19 (PDB ID: 4J9A). Ligands are shown in yellow. The ligands of 1HDC and DIG19 are carbenoxolone and digoxigenin, respectively. A, B: the overall structure of 1HDC and DIG19, respectively. C, D: Binding sites of 1HDC and DIG19, respectively.
