FIGURE 2.

Effects of formoterol and salmeterol on the a) production of leukotriene B₄ (LTB₄) (as a percentage of that of the control) following activation of neutrophils with N-formyl-l-methionyl-l-leucyl-l-phenylalanine (fMLP) (1 µM) and on b) intracellular cAMP (n=5–8). The median LTB₄ values (interquartile range) for the responses of control, drug-free, unstimulated and fMLP-activated neutrophils were 36 (27–110) and 200 (190–1667) pg·mL⁻¹, respectively. In the case of cAMP, the value for the drug-free control system was 7.76 (6.2–9) pmol·mL⁻¹. *: p<0.05 for comparison of formoterol or salmeterol with the corresponding control systems.