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. 2016 May 9;2(2):00096-2015. doi: 10.1183/23120541.00096-2015

TABLE 3.

Non-synonymous sequence variants of antibiotic resistance genes in Staphylococcus aureus and Pseudomonas aeruginosa populations of cystic fibrosis sputum metagenomes#

Organism Gene Amino acid substitution Patients n (samples n)
S. aureus gyrA p.Ser90Leu 2 (4 and 2 from each patient)
p.Leu576Phe 1 (1)
p.Arg843His 1 (1)
p.Thr833fs 1 (1)
p.Asp891_Glu892dup 1 (2)
rpoB p.Asp320Asn 1 (1)
parE p.Asn139Ser 2 (2 and 1 from each patient)
p.Gly530Asp 1 (1)
P. aeruginosa mexS p.Ala235Thr 1 (3)
p.Arg48His 1 (1)
mexI p.Ala782Glu 2 (1 from each patient)

#: 353 single-nucleotide polymorphisms were identified in total. The table displays a selection of rare non-conservative coding variants in targets of antimicrobial chemotherapy and antibiotic resistance determinants.