Temporal changes in mRNA levels of the renal RAS in male control and IUGR offspring by real-time PCR. Cortical renin mRNA expression (A), medullary renin mRNA expression (B), cortical angiotensinogen mRNA expression (C), medullary angiotensinogen mRNA expression (D), cortical angiotensin receptor type 1a mRNA expression (E), medullary angiotensin receptor type 1a mRNA expression (F), cortical angiotensin receptor type 1b mRNA expression (G), medullary angiotensin receptor type 1b mRNA expression (H), cortical ACE mRNA expression (I), and medullary ACE mRNA expression (J) in male control (n = 8) and male IUGR offspring (n = 7) at 12 mo of age and male control (n = 5) and male IUGR offspring (n = 6) at 18 mo of age. Data are expressed as fold changes relative to the mean expression level of the vehicle-treated control rats that were arbitrarily defined as 1. *P < 0.05 vs. age-matched counterpart. †P < 0.05 vs. IUGR at 12 mo of age. ‡P < 0.05 vs. control at 12 mo of age.