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Hippo-mutant phenotypes in Drosophila and mice. Electron micrographs of wild-type (A) and homozygous mutant Hippo (Hpo) gene (B) are shown. C: mouse liver from a wild-type animal at 2 mo of age. D: mouse liver from a Mst1−/−Mst2−/− conditional knockout animal. This image was reproduced from Ref. 18 with permission (Company of Biologists, Ltd., 2011).
