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Dysregulation of the mammalian Hippo pathway leads to tumorigenesis in vivo. A: liver from an ApoE/rtTA-YAP mouse raised on Dox for 8 wk, starting at 3 wk after birth. Note the presence of discrete nodules scattered throughout the liver (arrowheads). B: liver from an ApoE/rtTA-YAP mouse raised on Dox for 3 mo, starting at birth. Note the widespread development of hepatocellular carcinoma throughout the liver. This image was reproduced from Ref. 12 with permission (Elsevier, 2012).
