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The core Hippo pathway. KIBRA/NF2 promote phosphorylation and activation of MST 1/2 and Sav1. This in turn phosphorylates and activates LATS1/2 and MOB1. LATS 1/2 phosphorylates YAP/TAZ, leading to its cytoplasmic sequestration, inactivation, and degradation. When YAP/TAZ are dephosphorylated, they enter the nucleus to induce gene transcription by interacting with TEAD1-4 transcription factors.
