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. 2016 Jun 10;311(2):H371–H383. doi: 10.1152/ajpheart.00807.2015

Fig. 3.

Fig. 3.

Carv induces the expression of miR-199a-3p and miR-214 under sI/R in HL-1 and H9c2 cells. A–C: HL-1 cells were treated with either vehicle (DMSO) or 1 μM Carv for 4 h and subjected to either normoxia (basal) or sI/R. The expression of mature miR-199a-3p and miR-214 was detected using TaqMan microRNA assay. Carv elicits upregulation of miR-199a-3p and miR-214 in simulated I/R, but not under normoxic (basal) conditions. D–F: H9c2 cells were treated with 1 μM Carv for 4 h and subjected to either normoxia (basal) or sI/R. The expression of mature miR-199a-3p and miR-214 was detected using TaqMan microRNA assay. Carv activates the expression of miR-199a-3p and miR-214 in sI/R, but not under basal conditions. *P < 0.05 vs. DMSO or normoxia; **P < 0.01 vs. normoxia or DMSO; ***P < 0.001 vs. normoxia; n = 5 in each group.