Table 2.
AMC20W at 32 μM (n = 12) | MI20W at 32 μM (n = 8) | AMC20W at 1 μM (n = 9) | MI20W at 1 μM (n = 8) | |
---|---|---|---|---|
F0, kN/m2 | 66 ± 6 | 62 ± 9 | 30 ± 3* | 22 ± 3* |
Vmax, ML/s | 7.2 ± 0.6 | 4.8 ± 0.4†‡ | 2.1 ± 0.2* | 2.4 ± 0.8*† |
VPP, ML/s | 1.2 ± 0.1 | 0.8 ± 0.1‡ | 0.7 ± 0.1* | 0.7 ± 0.2* |
PP, kW/m3 | 14 ± 6.8 | 7.5 ± 1.4† | 5.9 ± 0.5* | 4.2 ± 0.6*† |
a/P0 | 0.05 ± 0.01 | 0.05 ± 0.08 | 0.39 ± 0.11* | 0.32 ± 0.11* |
FPP, kN/m2 | 12 ± 1.4 | 9.5 ± 1.4† | 9.4 ± 0.8* | 6.3 ± 1.0*† |
FPP/F0 | 0.18 ± 0.01 | 0.16 ± 0.01 | 0.32 ± 0.01* | 0.29 ± 0.02* |
CSA, μm2 | 12600 ± 2250 | 10700 ± 2380 | 20600 ± 2590 | 32000 ± 4710 |
Values are means ± SE. Mechanical parameters for MI20W and ACM20W trabeculae are tabulated. F0, peak isometric force; Vmax, peak unloaded shortening velocity; VPP, velocity at which peak power is attained, PP is the peak power; a/Po, curvature of the hyperbolic fit of the force-velocity data; FPP is the force at peak power; FPP/Po; ratio of force at peak isometric force; CSA, cross-sectional area of the trabeculae; ML, muscle length.
P < 0.05, significant [Ca2+] effect.
P < 0.05, significant effect of myocardial infarction (MI).
P < 0.05, interaction effect between [Ca2+] and MI.