Table 1.
Phloroglucinol and sildenafil increases sexual function of diabetic rats
| Sexual behavior parameters (unit) | Normal rat (n = 6) | Diabetic rats |
|||
|---|---|---|---|---|---|
| Water (n = 5) | Phloroglucinol (n = 5) | Sildenafil (n = 5) | Phloroglucinol + Sildenafil (n = 6) | ||
| ML (second) | 28.7 ± 3.8 | 56.8 ± 4.4$ | 42.0 ± 4.0∗ | 33.8 ± 5.0∗∗ | 27.8 ± 3.5∗∗ |
| IL (second) | 41.8 ± 3.9 | 80.8 ± 6.9$ | 56.0 ± 5.2∗ | 48.4 ± 4.7∗∗ | 40.5 ± 4.5∗∗ |
| EL (second) | 400.8 ± 26.3 | 270.4 ± 14.1$ | 321.4 ± 27.6∗ | 383.0 ± 16.1∗∗ | 410.5 ± 15.8∗∗ |
| MF (number) | 14.0 ± 2.1 | 5.4 ± 0.7$ | 9.4 ± 1.2∗ | 12.6 ± 1.1∗∗ | 14.2 ± 1.4∗∗ |
| IF (number) | 9.8 ± 0.6 | 3.4 ± 0.6$ | 6.4 ± 0.9∗ | 8.6 ± 0.8∗∗ | 10.0 ± 1.0∗∗ |
| PEI (second) | 345.3 ± 16.9 | 718.6 ± 23.2$ | 553.2 ± 24.6∗ | 499.8 ± 33.1∗∗ | 402.7 ± 12.5∗∗ |
Diabetes decreased sexual function of rats significantly ($P < .05). ML, IL, and PEI of rats with diabetes increased significantly ($P < .05), whereas MF, IF, and EL of diabetic rats decreased significantly ($P < .05) in comparison with normal healthy rats inferring the development of sexual dysfunction in diabetic rats.11, 20 Phloroglucinol, sildenafil, and Phloroglucinol + sildenafil increased sexual function of diabetic rats significantly (∗P < .05, ∗∗P < .01). One rat each from water, phloroglucinol and sildenafil–treated diabetic group did not respond to treatment and were excluded from statistical data calculation. Data are presented as mean ± standard error of mean. One-way ANOVA followed by Tukey's multiple comparison test was used for statistical analysis.