Table 2.
Sildenafil Relaxes Corpus Cavernosum of Normal and Diabetic Rats
| Concentration of phloroglucinol and sildenafil (μg/mL) | Normal rat (% relaxation) |
Diabetic rat (% relaxation) |
||||
|---|---|---|---|---|---|---|
| Water | Phloroglucinol | Sildenafil | Water | Phloroglucinol | Sildenafil | |
| 0.01 | 0.6 ± 0.2 | 0.8 ± 0.3 | 9.5 ± 1.7∗ | 0.5 ± 0.1$ | 0.4 ± 0.1 | 3.5 ± 0.9# |
| 0.1 | 1.2 ± 0.3 | 2.0 ± 0.4 | 19.3 ± 3.2∗ | 1.0 ± 0.2$ | 1.0 ± 0.2 | 11.3 ± 2.6# |
| 1 | 2.7 ± 0.5 | 6.2 ± 1.4 | 39.5 ± 5.8∗ | 1.6 ± 0.2$ | 2.0 ± 0.3 | 27.8 ± 5.2# |
| 10 | 4.7 ± 0.5 | 13.6 ± 1.9 | 85.7 ± 3.5∗ | 2.8 ± 1.1$ | 5.3 ± 1.0 | 65.8 ± 9.8# |
Table 2 illustrates effect of phloroglucinol and sildenafil on percent relaxation of phenylephrine precontracted isolated CCSMs of normal and diabetic rat in comparison with water. Sildenafil significantly (∗P < .05 vs water) relaxed CCSM of normal rat while phloroglucinol could not relax CCSM significantly. Relaxation effect of CCSMs of diabetic rat decreased significantly ($P < .05) in comparison with normal rats and sildenafil could significantly relax (#P < .05 vs water) CCSM of diabetic rat.11, 19, 21 n = 6. Values are presented as mean ± standard error of mean.