Table 2.

Change in genital temperature (°C) from baseline in over-the-counter lubricant vs alprostadil/DDAIP-HCl cream

Variable	Least squares mean		P value
Placebo	Alprostadil
Vestibule
Baseline	34.52	34.70	0.6672
Change to postdose average	−1.04	0.56	<0.0001
Maximum postdose temperature	34.00	36.32	<0.0001
Clitoris
Baseline	34.24	34.52	0.4447
Change to postdose average	−0.85	0.51	<0.0001
Maximum postdose temperature	33.85	36.16	<0.0001
Vulva
Baseline	33.98	34.22	0.5413
Change to postdose average	−0.84	0.26	<0.0001
Maximum postdose temperature	33.57	35.17	0.0014

DDAIP-HCl = dodecyl 2-(N,N-dimethyl amino) propionate plus dodecyl-2-(N,N-dimethyl amino) propionate hydrochloride.