FIGURE 4.

Newborn cells generated 3 days after UCN survived up to 1 month depending on the treatment administrated. (A) Illustrations of BrdU immunoreactivity in both the deafferented AVCN and PVCN at different time points (post-lesion D3 or D30) in UCN animals treated with NaCl-, AraC-, or Muscimol-intra-cerebroventricular infusion. Note that in AraC treated animals, no BrdU+ cells were observed at D3 (data not shown) or D30. Scale bar: 100 μm and n = 4 animals per group. (B) Histograms showing the effects of drug infusion (NaCl, AraC, or Muscimol) on the number of BrdU-immunopositive cells observed in the deafferented cochlear nuclei. Only values recorded on the lesioned side are illustrated. Different letters indicate significant differences between all other groups of animals. Analyzes were assessed by ANOVA followed by the Scheffé test for all VN and groups (p < 0.0001, see Table 3).