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. 2016 Aug 31;7:155. doi: 10.3389/fgene.2016.00155

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Copyright © 2016 Huang, Infante-Rivard and Labbe.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Theoretical (A) type 1 error and (B) power of models 1 (Unadjusted) and 2 (Adjusted) using Equation (A6) and (A7) in Appendix. (A) Type 1 Error (no association between disease and DSL where f₀ = f₁ = f₂ = 0.1). (B) Power (true association between disease and DSL where f₀ = 0.1, f₁ = 0.2, f₂ = 0.3). N, sample size (100, 300, and 500); f₀, penetrance for genotype 0 individuals; f₁, penetrance for genotype 1 individuals; f₂, penetrance for genotype 2 individuals.