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. 2016 Aug 31;10:72. doi: 10.3389/fncir.2016.00072

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Copyright © 2016 Chambers, Salazar and Polley.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Ouabain application to the cochlear round window induces profound denervation, while sparing cochlear amplification. The loss of afferent activity in the auditory nerve was estimated from the amplitude and threshold of wave 1b of the auditory brainstem response (ABR) 30 days after cochlear ouabain treatment. Outer hair cell function, measured via distortion product otoacoustic emission (DPOAE) threshold, is left intact. (A) DPOAE threshold by f2 frequency, measured at 30 days after ouabain (green) or sham (black) treatment. (B) ABR threshold by tone frequency. (C) ABR wave 1b amplitude vs. level, averaged across three tone frequencies per animal (8, 16 and 32 kHz). Inset shows example ABR waveforms in the sham and ouabain-treated conditions (16 kHz, 70 dB SPL). Arrow indicates wave 1b. Data and error bars are the mean ± SEM.