Table 5.

Average roughness (R3) value changes

		BG11001	Placebo	p1)	p2)
Arbitrary units (Average ± SD)
SV600 (R3)	Baseline	0.037 ± 0.012	0.040 ± 0.013	0.280
After 8 wk	0.030 ± 0.008	0.037 ± 0.012	0.004	0.004**
Difference3)	−0.007 ± 0.009	−0.003 ± 0.011	0.095
P4)	0.000∗∗	0.057
After 16 wk	0.032 ± 0.008	0.037 ± 0.011	0.008	0.014*
Difference5)	−0.005 ± 0.011	−0.003 ± 0.010	0.226
P4)	0.003∗∗	0.106
After 24 wk	0.031 ± 0.007	0.036 ± 0.010	0.010	0.017*
Difference6)	−0.006 ± 0.011	−0.004 ± 0.009	0.382
P4)	0.004∗∗	0.018∗

^∗p < 0.05 by Student t-test for comparison with placebo group.

^∗∗p < 0.01 by Student t-test for comparison with placebo group.

¹⁾Compared between groups: p-value by Student t-test.

²⁾Compared between groups: p-value by analysis of covariance (adjustment with baseline).

³⁾After 8 wk – baseline.

⁴⁾Compared within groups: p-value by paired t-test.

⁵⁾After 16 wk – baseline.

⁶⁾After 24 wk – baseline.