Fig. 2.
Effects of TG on pulmonary arterial remodeling in MCT-induced pulmonary hypertension rats. (A) Histological findings of the pulmonary arterial (arrows, 400×). Top, HE staining; bottom, EVG staining. HE and EVG stainings were performed according to common histopathological procedures. (B) A semiquantitative histological assessment of medial wall thickness was calculated as: WT (%) = (2 × WT/ED) × 100%. MCT markedly increased the percent medial wall thickness of the pulmonary arterial, and TG and l-arg attenuated MCT-induced medial wall thickening. The effects of TG and l-arg were inhibited by l-NAME. Results are represented as mean ± SD. * Statistical significance at p < 0.05 versus MCT group. # Statistical significance at p < 0.05 versus control group. ED, external diameter; EVG, elastic Van Gieson; HE, hematoxylin and eosin; l-NAME, NG-nitro-l-arginine methyl ester; MCT, monocrotaline; TG, total ginsenosides; WT, wall thickness.