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. 2015 Oct 22;40(3):285–291. doi: 10.1016/j.jgr.2015.09.005

Fig. 4.

Fig. 4

Effects of TG on p-ERK1/2, p-p38MAPK, p-JNK1/2, and MKP-1 protein expressions in pulmonary tissues in MCT-induced pulmonary hypertension rats. Eighteen days after treatment with TG, the protein expressions of p-ERK1/2, p-p38MAPK, p-JNK1/2, and MKP-1 in lungs were determined by Western blot. (A) Lanes 1, 2, 3, and 4 represent control, MCT, TG (40 mg/kg), and TG + L-N, respectively. Bands were quantified using a lumino-analyzer, and the data of (B) p-ERK1/2, (C) p-p38MAPK, (D) p-JNK1/2, and (E) MKP-1 expressions were expressed as fold increases normalized to β-actin expression. Results are represented as mean ± SD. a Statistical significance at p < 0.05 TG + L-N versus TG 40 mg/kg group. * Statistical significance at p < 0.05 versus MCT group. ** Statistical significance at p < 0.01 versus MCT group. # Statistical significance at p < 0.05 versus control group. L-N, NG-nitro-l-arginine methyl ester; MCT, monocrotaline; MKP-1, mitogen-activated protein kinase phosphatase-1; p38MAPK, p38 mitogen-activated protein kinase; p-ERK1/2, phospho-ERK1/2; p-JNK1/2, phospho-JNK1/2; TG, total ginsenosides.