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. 2016 Aug 31;9:79. doi: 10.3389/fnmol.2016.00079

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Copyright © 2016 Zhang, Wang, Yang, Xu, Ren, Li and Liu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Knockdown of ENOPH1 attenuates OGD-induced apoptosis-related protein expression in bEND3 cells. bEND3 cells transfected with siENOPH1 (siENO) or control siRNA (siCon) before exposing to OGD for 6 h. Apoptosis-related proteins were analyzed by western blot. (A) Upper panel: representative immunoblots showing the changes of cleaved and full length caspase-3 and PARP protein bands in bEND3 cells. β-actin was used as a loading control; bottom panel: quantitative data showed that OGD significantly increased the cleavage of caspase-3 and PARP and knockdown of ENOPH1 inhibited this change. *P < 0.05 vs. siCon; ^#P < 0.05 vs. siCon + OGD; n = 4. (B) Upper panel: representative immunoblots of Bax and Bcl-2 proteins; bottom panel: quantitative data showed that OGD significantly increased the ratio of Bax/Bcl-2 and knockdown of ENOPH1 inhibited this increase. *P < 0.05 vs. siCon; ^#P < 0.05 vs. siCon + OGD; n = 4.