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The effect of netupitant on (A) apomorphine (0.125 mg/kg, s.c.)-induced emesis in ferrets and (B) motion-induced emesis in Suncus murinus. Netupitant (0.03–0.3 mg/kg) or vehicle was administered orally 2 h prior to apomorphine (0.125 mg/kg, s.c.) or motion (4 cm horizontal displacement, 2 Hz for 10 min). Significant differences relative to vehicle treated animals (0 mg/kg) are indicated as ∗P < 0.05 or ∗∗P < 0.01 (one way ANOVA followed by Tukey’s multiple comparison testing).
