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. 2016 Aug 31;7:263. doi: 10.3389/fphar.2016.00263

FIGURE 2.

FIGURE 2

The effect of netupitant on cisplatin (10 mg/kg, i.p.)-induced emesis in ferret. Netupitant (0.03–0.3 mg/kg) or vehicle was administered orally 2 h prior to cisplatin (10 mg/kg, i.p.; t = 0). Data represents the mean ± SEM of (A) cumulative numbers of retches + vomits per 30 min, or (B) the total numbers of retches + vomits occurring over 8 h (n = 5–6). Significant differences relative to vehicle treated animals (0 mg/kg) are indicated as ∗P < 0.05, ∗∗P < 0.01 (one way ANOVA followed by Tukey’s multiple comparison testing).