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. 2016 Aug 31;7:263. doi: 10.3389/fphar.2016.00263

FIGURE 4.

FIGURE 4

A comparison of the effect of ondansetron plus aprepitant in combination with dexamethasone (O+A+D) with netupitant plus palonosetron in combination with dexamethasone (N1+P0.1+D) on cisplatin-induced retching and/or vomiting. Ondansetron, (1 mg/kg, p.o.), aprepitant (1 mg/kg, p.o.), palonosetron (0.1 mg/kg, p.o.), netupitant (1 mg/kg, p.o.), or dexamethasone (1 mg/kg, i.p.), or vehicle, were administered 15 min before cisplatin (5 mg/kg, i.p.; t = 0); the administration of ondansetron (1 mg/kg, p.o.) or dexamethasone (1 mg/kg, i.p.) or vehicle was repeated at 24 h intervals. Data represents the mean ± SEM of the total numbers of retches + vomits occurring in (A) 1, (B) 0–24, or (C) 24–72 h time intervals, as appropriate (n = 5–6). Significant differences relative to vehicle treated animals (V+V+V) are indicated as ∗P < 0.05, or ∗∗P < 0.01 (one way ANOVA followed by Tukey’s multiple comparison testing).