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. 2016 Aug 31;7:340. doi: 10.3389/fimmu.2016.00340

Figure 6.

Figure 6

NK cell cytokine-dependent responses through vaccination and after SIV infection. Frozen PBMCs obtained over the course of vaccination and challenge were thawed and stimulated overnight in the presence of different concentrations and combinations of IL-15, IL-12, and IL-18. (A–F) Expression of CD107a (top row) or IFN-γ (bottom row) by total NK cells in response to high (50 ng/ml) and low (5 ng/ml) concentrations of IL-15 (A,D); a high (250 ng/ml) dose of IL-12 in the presence (+) or absence (−) of a low (5 ng/ml) dose of IL-15 (B,E); and a high (250 ng/ml) dose of IL-18 in the presence (+) or absence (−) of a low (5 ng/ml) dose of IL-15 (C,F). Values of non-stimulated samples and negative controls have been subtracted. Data are shown as minimum to maximum boxes with all data points represented.