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. 2016 Jun 9;99(1):89–103. doi: 10.1016/j.ajhg.2016.04.013

Table 1.

Comparison between the Association Test on the Real Test Data for TG, BMI, and SBP Phenotypes and the Imputed Test Data in the NFBC Data

Phenotype rsID Real Test Dataa
Imputed Test Data
|Zimp-rimpZreal|
β se(β) Z-Score (Zreal) p value β se(β) Z-Score (Zimp) p Value
TG rs3923037 0.074 0.0149 4.96 7.14 × 10−7 0.0224 0.0083 2.700 0.006 0.17
rs6728178 0.076 0.0149 5.10 3.45 × 10−7 0.0267 0.0083 3.209 0.001 0.24
rs6754295 0.074 0.0149 4.94 7.91 × 10−7 0.0266 0.0083 3.197 0.001 0.32
rs676210 0.0752 0.0149 5.01 5.38 × 10−7 0.0250 0.0083 2.996 0.002 0.084
rs673548 0.0762 0.0149 5.08 3.81 × 10−7 0.02530 0.0083 3.031 0.002 0.08
rs1260326 −0.0807 0.0150 −5.37 8.15 × 10−8 −0.004 0.0084 −0.534 0.59 2.58
rs10096633 0.0819 0.0147 5.55 3.00 × 10−8 0.0191 0.0082 2.324 0.02 0.79
BMI rs987237 −0.074 0.0150 −4.97 6.63 × 10−7 −0.037 0.00929 −4.07 4.62 × 10−5 0.93
rs11759809 −0.074 0.0150 −4.95 7.35 × 10−7 −0.036 0.00931 −3.96 7.43 × 10−5 0.84
SBP rs782586 0.074 0.0149 4.96 7.43 × 10−7 0.036 0.01016 3.50 0.00047 0.37
rs782588 0.074 0.0149 4.94 8.14 × 10−7 0.035 0.01014 3.43 0.00061 0.32
rs782602 0.075 0.0150 5.01 5.53 × 10−7 0.034 0.01016 3.39 0.00071 0.23
rs2627759 0.070 0.0150 4.65 3.44 × 10−6 0.032 0.01016 3.12 0.00183 0.19
rs10486523 −0.073 0.0145 −4.98 6.62 × 10−7 −0.031 0.00999 −3.08 0.00207 0.06
rs9791555 −0.073 0.0145 −4.97 6.79 × 10−7 −0.031 0.00999 −3.07 0.00214 0.06
rs7799346 −0.073 0.0145 −4.98 6.52 × 10−7 −0.030 0.00999 −3.04 0.00235 0.09
rs6976779 0.069 0.0146 4.71 2.59 × 10−6 0.039 0.01000 3.94 0.00008 0.97
rs2846572 −0.067 0.0145 −4.62 3.94 × 10−6 −0.031 0.00998 −3.10 0.00194 0.19

Zimp and Zreal are the test statistics (Z-score) obtained from the imputed and original datasets, respectively. The last column is the difference between the imputed test statistics and the analytical test statistics.

a

The real test data is obtained from the NFBC data by removing the 500 individuals who are assumed to be missing in our experiment.