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. 2016 Jun 16;99(1):56–75. doi: 10.1016/j.ajhg.2016.05.006

Table 3.

SNP Transferability in AA Individuals at 13 EA-Associated Type 2 Diabetes Quantitative Trait SNPs

Locusb Index SNPc Chr Allelesd EA Associationa
 AA Associationa
EAFe Effectf SE EAFe Effectf SE p
Fasting Glucose-Associated Loci
MTNR1B rs10830963 11 G/C 0.30 0.067 0.003 0.08 0.089 0.012 9.29 × 10–15
G6PC2 rs560887 2 C/T 0.70 0.075 0.003 0.93 0.059 0.013 2.67 × 10–06
ADCY5 rs11708067 3 A/G 0.78 0.027 0.003 0.85 0.036 0.008 6.27 × 10–06
GCKR rs780094 2 C/T 0.62 0.029 0.003 0.82 0.032 0.008 2.03 × 10–05
GCK rs4607517 7 A/G 0.16 0.062 0.004 0.11 0.041 0.010 6.84 × 10–05
GLIS3 rs7034200 9 A/C 0.49 0.018 0.003 0.63 0.019 0.006 1.82 × 10–03
KL rs576674 13 G/A 0.15 0.017 0.003 0.60 0.018 0.006 2.06 × 10–03
SLC30A8 rs13266634 8 C/T 0.68 0.027 0.004 0.90 0.024 0.010 1.82 × 10–02
MADD rs7944584 11 A/T 0.75 0.021 0.003 0.95 0.029 0.014 3.37 × 10–02
DGKB-TMEM195 rs2191349 7 T/G 0.52 0.030 0.003 0.60 0.013 0.006 3.70 × 10–02
GRB10 rs6943153 7 T/C 0.34 0.015 0.002 0.68 0.012 0.006 4.81 × 10–02
Fasting Insulin-Associated Locig
COBLL1-GRB14 rs7607980 2 T/C 0.87 0.027 0.004 0.84 0.042 0.008 2.85 × 10–07
GCKR rs780094 2 C/T 0.62 0.032 0.004 0.82 0.025 0.008 1.92 × 10–03

SNP transferability is defined as the association p < 0.05 in AA and sharing the same trait-raising allele between EA and AA. 13 EA-identified T2D QT SNPs in 12 loci, including 10 fasting glucose loci, 1 fasting insulin locus, and 1 locus associated with both.

a

EA Association results refer to the association results using samples of European ancestry in previous publications;8, 9, 10 AA Association results refer to the association results using AAGILE samples of African ancestry assembled in this study.

b

For ease of comparison to previous studies, the loci are named based on the historically identified nearest protein-coding gene or genes to the index SNP in European ancestry.

c

Index SNPs are the most significant SNPs previously reported in MAGIC publications. All of these SNPs reach genome-wide significant level (p < 5 × 10–8) in the original study.

d

EA trait-raising allele/other allele.

e

Frequency of EA trait-raising allele.

f

Effect of EA trait-raising allele ([mmol/L] for fasting glucose and [pmol/L] for fasting insulin per trait-raising allele).

g

The association with BMI-adjusted fasting insulin.