Table 5.

Two Previously Undescribed Loci Associated with Fasting Insulin in African Ancestry Individuals

SNPa	Chr	Position (build 36)	Nearest Gene	Allelesb	African Ancestry Associationc				European Ancestry Association				Trans-ethnic Association
NAAd	EAFe	Effectf	p	NEAd	EAFe	Effectf	p	NTotald	log(BF)
rs213676	X	93358147	FAM133A	C/G	14,043	0.98	0.147	2.37 × 10–8	0g	NA	NA	NA	14,043	6.26
rs6450057	5	51683121	PELO	T/C	20,853	0.4	0.027	3.11 × 10–6	52,372	0.37	–0.011	9.21 × 10–5	73,225	7.1

^aTwo SNPs in previously undescribed loci are associated with fasting insulin at genome-wide significance, i.e., p < 5 × 10^–8 in AA individuals or with logBF > 6 in trans-ethnic meta-analysis.

^bTrait-raising allele/other allele in the sample of African ancestry.

^cAssociation results from the samples of African ancestry based on the joint analysis of samples from stage 1 and stage 2.

^dN_AA: the sample size of African ancestry; N_EA: the sample size of European ancestry; N_total: total sample size of EA and AA.

^eFrequency of effect allele (i.e., AA trait-raising allele).

^fEffect of AA trait-raising allele ([pmol/L] per trait-raising allele).

^gAssociation analysis result is unavailable in MAGIC EA samples because the original MAGIC¹⁰ effort analyzed only autosomal variants.