Table 2.

Previously Unreported Associations with MPV

rsID	Ref/Alt	Function	Gene	European Ancestry (EA)						Combined All Ancestry (All)
Discovery (n = 34,021)			Replication (n = 15,519)		Combined	Discovery (n = 41,529)			Replication (n = 16,088)		Combined
EAF	Beta	p Value	Beta	p Value	p Value	EAF	Beta	p Value	Beta	p Value	p Value
rs6687605	T/C	missense	LDLRAP1∗	0.53	0.046	8.27 × 10−12	0.025	3.74 × 10−2	1.80 × 10−9	0.51	0.046	9.92 × 10−11	0.024	3.58 × 10−2	3.80 × 10−11
rs56043070a	G/A	splice	GCSAML∗	0.069	0.094	1.30 × 10−9	0.19	4.48 × 10−16	1.12 × 10−21	0.064	0.092	2.25 × 10−10	0.19	3.66 × 10−16	2.42 × 10−22
rs1339847a	G/A	missense	TRIM58	0.10	−0.10	1.47 × 10−13	−0.037	5.44 × 10−2	9.31 × 10−13	0.10	−0.11	2.18 × 10−17	−0.032	9.77 × 10−2	1.06 × 10−15
rs34968964a	G/C	missense	IQGAP2	0.0049	0.32	7.65 × 10−9	0.12	9.18 × 10−2	1.99 × 10−8	0.004	0.32	2.11 × 10−9	0.11	0.106	8.18 × 10−9
rs34950321a	C/T	missense	IQGAP2∗	0.018	0.18	7.80 × 10−10	0.14	1.49 × 10−3	6.03 × 10−12	0.016	0.17	2.61 × 10−9	0.14	1.59 × 10−3	1.86 × 10−11
rs34592828a	G/A	missense	IQGAP2∗	0.037	0.22	1.72 × 10−27	0.16	2.73 × 10−9	1.61 × 10−34	0.032	0.23	1.68 × 10−31	0.16	2.95 × 10−9	2.98 × 10−38
rs1012899a	G/A	missense	LRRC16A	0.77	0.051	1.40 × 10−7	0.012	0.417	1.24 × 10−6	0.77	0.042	1.32 × 10−6	0.016	0.273	2.50 × 10−6
rs664370	A/G	missense	PXT1∗	0.30	−0.034	8.03 × 10−5	−0.025	5.61 × 10−2	1.39 × 10−5	0.35	−0.042	5.77 × 10−8	−0.028	2.78 × 10−2	7.23 × 10−9
rs2343596a	C/A	intron	ZFPM2	0.31	0.062	2.02 × 10−13	0.012	0.357	3.32 × 10−11	0.38	0.052	1.59 × 10−11	0.012	0.339	4.35 × 10−10
rs55895668a	T/C	missense	PLEC	0.43	−0.042	5.94 × 10−7	−0.013	0.350	2.19 × 10−6	0.47	−0.041	1.23 × 10−7	−0.011	0.409	5.97 × 10−7
rs4909945	T/C	missense	MRVI1∗	0.68	−0.048	1.25 × 10−8	−0.035	8.41 × 10−3	5.19 × 10−10	0.71	−0.041	3.96 × 10−7	−0.035	7.42 × 10−3	1.06 × 10−8
rs11125	A/T	missense	LGALS3	0.078	−0.091	1.55 × 10−8	−0.037	0.117	2.76 × 10−8	0.07	−0.09	4.22 × 10−9	−0.037	0.117	7.21 × 10−9
rs2010875a	C/T	missense	PLEKHO2∗	0.14	−0.076	1.33 × 10−7	−0.042	1.62 × 10−2	2.10 × 10−8	0.15	−0.063	3.01 × 10−7	−0.042	1.62 × 10−2	2.43 × 10−8
rs10512472a	T/C	missense	SLFN14∗	0.18	−0.059	1.37 × 10−8	−0.059	1.96 × 10−4	1.12 × 10−11	0.18	−0.058	3.15 × 10−10	−0.059	1.20 × 10−4	1.67 × 10−13
rs35385129	C/A	missense	PVR∗	0.16	−0.058	6.24 × 10−8	−0.044	7.36 × 10−3	2.01 × 10−9	0.15	−0.055	3.00 × 10−8	−0.043	7.13 × 10−3	8.79 × 10−10
rs2243603	C/G	missense	SIRPB1	0.77	0.044	5.89 × 10−6	0.077	0.167	2.62 × 10−6	0.79	0.049	4.58 × 10−8	0.088	7.78 × 10−2	1.25 × 10−8
rs1018448	A/C	missense	ARFGAP3∗	0.55	0.056	1.13 × 10−12	0.051	1.78 × 10−5	1.04 × 10−16	0.60	0.055	1.52 × 10−13	0.05	2.16 × 10−5	1.68 × 10−17
rs1997715	G/A	3′ UTR	ZXDB∗	0.26	0.048	1.93 × 10−9	0.084	5.83 × 10−2	4.26 × 10−10	0.35	0.04	4.58 × 10−8	0.08	3.99 × 10−2	8.88 × 10−9

We show variants in previously unreported MPV loci (n = 18) and retained after conditional analyses in European ancestry (EA) (p < 2.59 × 10⁻⁷) and all ancestry (All) (p < 2.20 × 10⁻⁷) analyses. Associations in African ancestry (AA) had previously been reported in the literature (Table S11). Asterisk (^∗) indicates variants (11/18) that showed evidence of replication (p < 0.05, same direction of effect). If multiple genes/transcripts were annotated to a variant, the transcript more expressed in Eicher et al.³² (Table S22) was selected. Full results and annotations are available in Table S7. Abbreviations are as follows: MPV, mean platelet volume; PLT, platelet count; REF, reference allele; ALT, alternate allele; EAF, effect allele frequency.

^aPrevious association with PLT.