Table 4.
Intersection of Platelet-Associated Variants with RBC and WBC Traits
| SNP | MarkerName | Gene | PLT | Trait | Other Blood Cell |
|---|---|---|---|---|---|
| rs855791 | chr22: 37,462,936 | TMPRSS6 | ↓ | MCH, MCV, HGB MCHC, HCT | ↑ |
| rs855791 | chr22: 37,462,936 | TMPRSS6 | ↓ | RDW | ↓ |
| rs55707100 | chr15: 43,820,717 | MAP1A | ↑ | HGB, MCH, HCT, MCHC | ↓ |
| rs174583 | chr11: 61,609,750 | FADS2 | ↑ | RDW | ↓ |
| rs174583 | chr11: 61,609,750 | FADS2 | ↑ | HGB, RBC, HCT, MCHC | ↑ |
| rs738409 | chr22: 44,324,727 | PNPLA3 | ↓ | HCT, HGB | ↑ |
| rs3091242 | chr1: 25,674,785 | TMEM50A | ↓ | RDW | ↑ |
| rs1050331 | chr7: 44,808,091 | ZMIZ2 | ↑ | MCH, MCV | ↓ |
| rs1050331 | chr7: 44,808,091 | ZMIZ2 | ↑ | WBC | ↑ |
| rs6734238a | chr2: 113,841,030 | IL1F10/IL1RN | ↑ | MCH | ↓ |
| rs6734238a | chr2: 113,841,030 | IL1F10/IL1RN | ↑ | WBC, NEU | ↑ |
| rs12566888 | chr1: 156,869,047 | PEAR1 | ↑ | WBC, NEU, MON | ↓ |
| rs3865444 | chr19: 51,727,962 | CD33 | ↓ | WBC | ↓ |
| rs6136489 | chr20: 1,923,734 | SIRPA/LOC727993 | ↓ | WBC, LYM | ↓ |
| rs2256183a | chr6: 31,380,529 | MICA | ↑ | BAS | ↑ |
| rs12692566 | chr2: 160,676,427 | LY75-CD302 | ↓ | WBC | ↓ |
We cross-referenced novel variants associated with platelet count (PLT) and/or mean platelet volume (MPV) in RBC and WBC association analyses in the Blood Cell Consortium (BCX). Here, we show RBC/WBC-associated platelet variants with p < 0.0001. Full details of RBC/WBC associations are shown in Tables S16 and S17. Arrows denote direction of effect for the platelet and other blood cell trait(s). Abbreviations are as follows: BCX, Blood Cell Consortium; RBC, red blood cell; WBC, white blood cell; PLT, platelet count; MCH, mean corpuscular hemoglobin; MCV, mean corpuscular volume; HGB, hemoglobin; MCHC, mean corpuscular hemoglobin concentration; HCT, hematocrit; RDW, red blood cell distribution width; PLT, platelet count; NEU, neutrophil; MON, monocyte; LYM, lymphocyte; BAS, basophil.
Marker not replicated in platelet analyses.