Table 5.
Overlap of Associations of Platelet Count and Mean Platelet Volume Variants with Platelet Reactivity
| rsID | Gene | PLT | MPV | Agonist(s)a | Direction of Effectsb |
|---|---|---|---|---|---|
| rs12566886 | PEAR1 | ↑ | ↓ | epi, ADP, collagen | ↓↓↓ |
| rs10761731 | JMJD1C | ↑ | ↓ | epi, ADP | ↑↑ |
| rs12355784 | JMJD1C | ↑ | ns | epi | ↑ |
| rs342293 | PIK3CG | ↓ | ↑ | epi | ↓ |
| rs4909945 | MRVI1 | ns | ↓ | epi, ADP | ↓↓ |
| rs2958154 | PTGES3 | ↓ | ↑ | collagen | ↑ |
| rs12883126 | LINC00523 | ↑ | ns | epi | ↑ |
| rs892055 | RASGRP4 | ↑ | ns | epi | ↓ |
Variants were examined using platelet reactivity phenotypes (Table S18) in GeneSTAR and the Framingham Heart Study (FHS). Arrows denote direction of effect for platelet count (PLT), mean platelet volume (MPV), and platelet reactivity (p < 0.001). Multiple arrows refer to direction for respective agonist for platelet reactivity. Detailed association results for platelet reactivity are given in Table S19. Abbreviations are as follows: PLT, platelet count; MPV, mean platelet volume; ns, not significant (p > 0.05); epi, epinephrine.
Platelet reactivity associations with p < 0.001.
Collagen measurements reflect lag time to aggregation, so direction of effect has been flipped to denote a negative direction of effect as less reactive and positive direction of effect as more reactive.