Table 4.
A Summary of Gene-Based Association p Values with Data from the OHTS
| Chromosome | Gene | SKAT+ (0.5) | SKAT+ (0.75) | SKAT | SKAT-O |
|---|---|---|---|---|---|
| 2 | HAGLROS | 3.525 × 10−5 | 4.821 × 10−5 | 5.918 × 10−5 | 8.619 × 10−5 |
| 6 | EXOC2 (MIM: 615329) | 2.725 × 10−4 | 3.285 × 10−4 | 3.327 × 10−4 | 2.951 × 10−5 |
| TRERF1 (MIM: 610322) | 2.976 × 10−5 | 2.586 × 10−5 | 3.427 × 10−5 | 7.390 × 10−5 | |
| 7 | NDUFA5 (MIM: 601677) | 1.822 × 10−5 | 5.848 × 10−5 | 1.042 × 10−4 | 1.129 × 10−4 |
| IQUB | 1.680 × 10−5 | 4.322 × 10−5 | 7.473 × 10−5 | 8.301 × 10−5 | |
| 15 | MTMR10 (MIM: 208500) | 4.767 × 10−3 | 5.528 × 10−3 | 5.592 × 10−3 | 3.536 × 10−5 |
| SNAP23 (MIM: 602534) | 3.355 × 10−5 | 1.217 × 10−4 | 1.486 × 10−4 | 1.359 × 10−4 | |
| HAUS2 (MIM: 613429) | 9.859 × 10−5 | 1.930 × 10−4 | 2.581 × 10−4 | 2.784 × 10−4 | |
| MYL12BP1 | 4.672 × 10−5 | 1.155 × 10−4 | 1.693 × 10−4 | 1.748 × 10−4 | |
| 16 | TXNDC11 | 7.867 × 10−5 | 9.746 × 10−5 | 8.708 × 10−5 | 9.013 × 10−5 |
Genes were selected if any statistic had a p value less than 0.0001 in the non-Hispanic white-only sample. SKAT+ (0.5) refers to SKAT+ method using 50% of the subjects for its p value calculation. SKAT+ (0.75) uses 75% of the subjects.